Cut and paste this URL to share the unmodified register and value:
https://regviz.com/r/stm32/stm32u5/STM32U535/DBGMCU/APB1HFZR#0x0
Debug MCU APB1H peripheral freeze register
I2C4 stop in debug
LPTIM2 stop in debug
https://github.com/modm-io/cmsis-svd-stm32